Selective Androgen Receptor Modulators: Recent Experience and Clinical Uses

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors according to each SARM’s chemical structure. Because of this, SARMs cause anabolic cellular activity while avoiding most of the negative effects of now available anabolic steroids. SARMs have been studied from the treating cancer of the breast and cachexia and also have also been used as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.

Aim
To present the background, mechanisms, current and potential clinical applications, and also risks and benefits of SARMs.

Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, cancer of the breast, benign prostatic hyperplasia, libido, and muscle. Both preliminary research and studies were included.

Main Outcome Measure
To complete overview of peer-reviewed literature.

Results
Though there are still no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses for these compounds. Preliminary research has centered on the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability using a paucity of drug interactions. Early studies have demonstrated potential ways to use SARMs within the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with good success.

Conclusion
SARMs have a lot of possible clinical applications, with promise to the safe utilization in treating cachexia, BPH, hypogonadism, cancer of the breast, and prostate cancer.

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