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SINCE Wwii, medical science has progressed to some stage where competitive medications are around to treat the same ailment in several people. It’s not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall glance at the various factors that decide picking a a specific drug.

Safety: The subsequent sub-criteria has to be considered beneath the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug even when it has certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the opportunity side-effect of addiction.

* Long-term safety: medication directory may be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals react to create a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon due to the metabolism. This causes a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually generate the same influence on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both prescription medication is more serious.

Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability should be taken into account. Efficacy: A medication is just not equally great at all patients. By way of example, some patients with depression or anxiety disorders experience respite from escitalopram, but there are numerous that don’t, who therefore should be prescribed another anti-depressant. The rate of onset of therapeutic action is a vital step to be regarded too.

Cost: Cost doesn’t imply the price of acquiring a particular medicine alone. It should also cover the price of treatments for a complication that will arise while using another drug. Example: In the person who insists on taking alcohol but needs to be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (like tricyclics) could cause a whole new problem in such patients, which could require a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.

Simple treatment: The simplest mode of administration is preferred. If you have a choice between an injection and oral administration, rogues is preferred in the event the efficacy of both modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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